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Spaghetti Scenarios · Global risk

Severe natural pandemic

A virus or bacterium of natural origin spreads across the planet, sickens a large share of the population and overwhelms hospitals, as happened with the 1918 flu or with COVID-19. Severe pandemics recur throughout history: the question is not whether there will be another, but when, and how prepared we will be.

The world learned to make vaccines in months, but it still has the same number of hospital beds and, right now, an open international health emergency.

Pathogens with sustained human-to-human transmission

8,116 cases

confirmed in the Ebola outbreak that began in May 2026, which does spread from person to person. Bird flu, by contrast, has infected 1,003 people since 2003 without spreading between humans.

▼ Went from 3,605 cases at the end of July to 8,116 at the end of September 2026

Observed case fatality

47.8%

of people with confirmed bird flu died (479 of 1,003, since 2003). In the 2026 Ebola outbreak, the case fatality rate was 44% at the end of July.

Hospital capacity

3.3

hospital beds per 1,000 people worldwide (2021). In 2000 there were 3.1.

■ Between 2.7 and 3.3 beds per 1,000 people since 2000

Vaccine development time

326 days

is how long it took for the first COVID-19 vaccines to start being given. For polio, 47 years passed after the virus was identified.

▲ From decades to less than a year; the agreed goal is 100 days

0.3% – 1.9%probability per year
20% – 76%probability between 2025 and 2100

Cumulative probability of it happening

UnlikelyPossibleVery likelyAlmost certain0%20%50%80%100%20252040206020802100today
Year: 2050

Nine international health emergencies in 17 years

Every time an outbreak threatens to cross borders, the world's highest health alert is triggered. This is the list since the current system has existed, with the two decisions that changed it.

  1. 2009Influenza A: the first international health emergency in history, declared on April 25.
  2. 2014Polio: the international spread of the virus is declared an emergency on May 5. It is still open.
  3. 2014Ebola in West Africa: emergency declared on August 8, with 1,779 cases and 961 deaths up to that point.
  4. 2016Zika: on February 1 an emergency is declared over the cases of babies with birth defects.
  5. 2019Ebola in eastern Congo: emergency declared on July 17.
  6. 2020COVID-19: emergency on January 30, with 98 cases outside China and no deaths; pandemic on March 11.
  7. 2022Mpox: first emergency, due to its spread to countries where the virus had not been seen.
  8. 2024Mpox again: on August 14, with more than 15,600 cases and 537 deaths that year in Africa.
  9. 2024More than 200 scientists from more than 50 countries review 1,652 microbes to decide which ones to monitor and research first.
  10. 2025On September 19 revised health regulations enter into force, adding a higher alert level: the pandemic emergency.
  11. 2026Ebola in Congo and Uganda: emergency declared on May 17. It did not reach the level of a pandemic emergency.

The 2026 Ebola outbreak and polio are the two emergencies still open in October 2026.

What the last pandemic left behind

14.9 millionexcess deaths in 2020 and 2021
13.3 to 16.6million: the margin of that estimate
326 daysuntil the first vaccines
100 daysis the agreed goal for next time

How long it takes to get a vaccine

Years between the moment the microbe that causes the disease is identified and the moment the vaccine is approved.

Polio47 years
1908 → 1955
Ebola43 years
1976 → 2019
Whooping cough42 years
1906 → 1948
Hepatitis B16 years
1965 → 1981
Measles10 years
1953 → 1963
COVID-19less than 1 year
2020 → 2020

The agreed goal for the next threat with pandemic potential is 100 days.

Hospital beds worldwide

Hospital beds per 1,000 inhabitants. Move the slider to see each year: in two decades the figure barely moved.

01234200020052010201520213.3
  • Hospital beds3.3beds per 1,000 people in 2021

2021 is the latest year with published global data.

Bird flu, under watch

1,003people infected since 2003
479of them died
25 countrieshave reported a human case
71human cases in the United States since 2024

No sustained transmission between people has been identified: the circulating viruses still do not spread easily from human to human. The virus reached U.S. dairy cows in March 2024.

Severe natural pandemic

Impact
Major (4)
Probability
Unlikely to Very likely (2–4)
Over the horizon
0.3%–1.9% per year → 20%–76% in 2025–2100
Timeframe
Recurring on a century scale
Score
8 – 16
Confidence
Medium
Reversibility
Partially reversible or persistent
Classification
Biological

Signals to watch

  • Pathogens with sustained human-to-human transmission
  • Observed case fatality
  • Hospital capacity
  • Vaccine development time

Possible human action

  • Epidemiological surveillance
  • Rapid vaccine capacity
  • Biosecurity